Abstract—Heavy metal and their salts are considered as very important group of environmental pollutant which in small quantities may be essential nutrients that protect your health, yet in larger quantity it become toxic and dangerous to human being. One of the major mechanisms behind heavy metal toxicity has been attributed to oxidative stress. This study aimed to invetigate the effect of Arsenic (As), Cadmium (Cd), and Mercury (Hg) on Malondialdehyde (MDA) and Advanced Oxidation Protein Products (AOPP) concentration in vitro. MDA and AOPP level are increased during the exposure of As, Cd, and Hg. Furthermore MDA level positively correlated with AOPP level. It can be concluded from presented study that Arsenic, Cadmium and Mercury caused the increasing of MDA and AOPP levels. This study also suggested that the exposure of Arsenic, Cadmium and Mercury can caused oxidative stress and inflammation.

Index Terms—arsen, AOPPs, cadmium, malondialdehyde, mercury

Cite: Iwan Aflanie, Ruslan Muhyi, and Eko Suhartono, "Effect of Heavy Metal on Malondialdehyde and Advanced Oxidation Protein Produtcs Concentration: A Focus on Arsenic, Cadmium, and Mercury," Journal of Medical and Bioengineering, Vol. 4, No. 4, pp. 332-337, August 2015. Doi: 10.12720/jomb.4.4.332-337