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Mesenchymal Stem Cell Infusion in Chronic Renal Failure Patients

Hala Gabr and Rania A. Zayed
Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt
Abstract—The recently discovered therapeutic potential of mesenchymal stem cells (MSCs) has initiated development of various therapeutic options in a number of diseases. These therapeutic options may help in improving patients’ quality of life, through preventing disease progression. Methods: Bone marrow samples from 11 chronic renal failure patients were cultured in appropriate culture medium to isolate MScs. MSCs obtained were identified by their plastic adherence property; positive expression of CD 271, CD 105 and negative expression of CD 34, CD 45 using flowcytometry. Harvested MScs were injected to the patients through transfemoral catheter every other week for six months. Results: The patients were followed up to detect any change in their laboratory tests. Follow up revealed a statistically significant improvement in blood urea, creatinine levels and GFR of p value 0.000. Conclusion: Stem cells are a promising therapeutic approach to ameliorate condition in chronic renal failure patients.

Index Terms—chronic renal failure, autologous stem cell, transplantation

Cite: Hala Gabr and Rania A. Zayed, "Mesenchymal Stem Cell Infusion in Chronic Renal Failure Patients," Journal of Medical and Bioengineering, Vol. 4, No. 4, pp. 329-331, August 2015. Doi: 10.12720/jomb.4.4.329-331
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