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Antidiabetic and Antioxidant Activity of Jackfruit (Artocarpus Heterophyllus) Extract

Agung Biworo1, Efrilia Tanjung2, Iskandar3 , Khairina4, and Eko Suhartono5
1.Medical Pharmacology Department, School of Medicine, Lambung Mangkurat University, Banjarmasin, Indonesia
2.Datuk Sanggul General Hospital Rantau, South Kalimantan, Indonesian
3.Research Unit Mutiara Bunda Mother and Child Hospital, Martapura, South Kalimantan, Indonesian
4.School of Medicine, Lambung Mangkurat University, Banjarmasin, Indonesia
5.Medical Chemistry and Biochemistry Department, School of Medicine, Lambung Mangkurat University, Banjarmasin, Indonesian
Abstract—The Artocarpus heterophyllus (Jackfruit) is a species of tree of the mulberry family Moraceae. The plants of Artocarpus species have been used by traditional folk medicine in Indonesia. can be useful as anti-bacterial, anti-diabetic, anti-inflammatory, antioxidant and anti-helmintics. The present study was aimed to evaluate antidiabetic and antioxidant activity of aqueous extract of Jackfruit. The antidiabetic activity were determined by inhibition of haemoglobin glycation method. Phytochemical constituent like ascorbic acid, β-carotene and lycopene also determined. Antioxidant activity was measured by hydroxl radical and hydrogen peroxide scavenging activity, and chellating effect of ferrous iron. From the result of this study we can see the increasing of haemoglobin glycation concentration is followed by the increasing of jackfruit extracts concentration. From this study also we found the IC 50 of jackfruit exctracts is 56,43 %. The result of this study also showed that the extract of jackfruit has a phytochemical constituent with ascorbic acid is the highest, and followed by β-carotene and lycopene. Jackfruit also has antioxidant activity. The highest antioxidant activity is scavenging hydroxyl radical activity and followed by scavenging hydrogen peroxide and chellating of ferrous iron. The result of this study suggest that the jackfruit extract potential as an diabetic agent.

Index Terms—antidiabetic, antiglycation, antioxidant activity, jackfruit

Cite: Agung Biworo, Efrilia Tanjung, Iskandar, Khairina, and Eko Suhartono, "Antidiabetic and Antioxidant Activity of Jackfruit (Artocarpus Heterophyllus) Extract," Journal of Medical and Bioengineering, Vol. 4, No. 4, pp. 318-323, August 2015. Doi: 10.12720/jomb.4.4.318-323
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