Abstract—The authors reported a rare case of the occurrence of a high-grade glioma secondary to a vascular malformation (VM) lesion in the same location in a 32-year-old man. Initial brain CT scan revealed a left frontal hematoma with perifocal edema. Furthermore, the Susceptibility weighted imaging (SWI) revealed many tortuous vessels around the hemotoma. But the Digital Subtraction Angiography (DSA) showed no obvious VM and aneurysm. At last, the histological section examination showed a VM with haemorrhage after hematoma evacuation. Sixteen months later, the Magnetic Resonance Imaging (MRI) revealed a multiple cystic space-occupying lesion in the left frontal lobe involving in the left lateral ventricle, with midline shift, and the contrast enhanced area around the cystic lesion. The patient underwent excision of the lesion. The final histopathological examination of the specimen revealed a high-grade glioma with haemorrhage, necrosis and cystic degeneration. A vicious circle of aberrant neoangiogenesis and hypoxia or/and an excessive inflammatory might explain this situation. Routine imaging reexamination might be suggested for some patients suffering with VM.

Index Terms—arteriovenous malformation, vascular malformation, glioma

Cite: Qiao Wang, Haogeng Sun, Zhikuan Yu, and Houfu Deng, "The Occurrence of a High-grade Glioma Secondary to Vascular Malformation: A Case Report," Journal of Medical and Bioengineering, Vol. 4, No. 3, pp. 259-262, June 2015. Doi: 10.12720/jomb.4.3.259-262