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The Insulin Like Growth Factor-1(IGF-1) and Insulin Binding Protein-3 (IGFBP-3) Level As Predictor Biomarker of Chronic Kidney Disease (CKD) Patients in Indonesia

Titiek Hidayati1, Ahmad Hamim Sadewa2, Jarir Aththobari2 , and Marstyawan HNES4
1.Faculty of Medicine and Health Sciences, Family Medicine and Public Health Department, Universitas Muhammadiyah Yogyakarta, Indonesia
2.Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia
Abstract—This research aimed to identify (i). the IGF-1 and IGFBP-3 level of ESRD and non ESRD populations in Indonesia and (ii). The correlation between IGF-1 and IGFBP-3 level and ESRD incidences.This case control study was carried out in Yogyakarta among 159 volunteers. The result showed that among respondents whose data were successfully and completely collected involved 159 volunteers. The result of bivariate analysis showed level, IGF-1 and IGFBP-3 plasma level, DM history and hypertensive illness history had correlation with ESRD incidences. Lower IGF-1 level and higher IGFBP-3 level have highest OR value and can be used as predictor biomar ESRD incidence. Based on the research result, it is concluded that there difference in IGF-1 and IGFBP-3 plasma level between ESRD and non- ESRD patients in Indonesia. The IGF-1 and IGFBP-3 plasma level have correlation with ESRD incidence in Indonesia.

Index Terms—IGF-1 level; IGFBP-3 level; ESRD; biomarker predictorl; odds ratio

Cite: Titiek Hidayati, Ahmad Hamim Sadewa, Jarir Aththobari, and Marstyawan HNES, "The Insulin Like Growth Factor-1(IGF-1) and Insulin Binding Protein-3 (IGFBP-3) Level As Predictor Biomarker of Chronic Kidney Disease (CKD) Patients in Indonesia," Journal of Medical and Bioengineering, Vol. 4, No. 3, pp. 254-258, June 2015. Doi: 10.12720/jomb.4.3.254-258
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