Abstract—Mitragyna speciosa Korth (MS) leaves are widely used as a traditional remedy. The main aim of the present study was to observe the subacute toxicity of MS crude extract on the liver, kidney and uterus in female Sprague Dawley rats. Thirty two rats (150-200g) were randomlydivided into four groups: control acute (CA); controlsubacute (CS); experimental acute (EA) and experimentalsubacute (ES). CA and CS groups were only given 15% Tween-80. Group EA rats were administered single oraldose of 1000mg/kg MS extract for 14 days. Group ES ratswere administered repeated dose of 500 mg/kg MSmethanol for 28 days. Liver of ES group showed severe sinusoidal congestion with enlarged hepatocytes and numerous vacuolation compared to EA group. The lining ofepithelial cells of uterine tissue in ES group showed more vacuolated cells with increasing in height. No changes were observed in kidney with both doses.

Index Terms— Mitragyna speciosa, subacute, toxicity, liver, kidney, uterus

Cite: Rani Sakaran, Faizah Othman, Ibrahim Jantan, Zar Chi Thent, and Srijit Das, "Effect of Subacute Dose of Mitragyna Speciosa Korth Crude Extract in Female Sprague Dawley Rats," Journal of Medical and Bioengineering, Vol. 3, No. 2, pp. 98-101, June 2014. Doi: 10.12720/jomb.3.2.98-101