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Anti-Inflammatory and Acetylcholinesterase Inhibition Activities of Globularia Alypum

Daycem. Khlifi1,2,3, Rabiaa Manel. Sghaier3, Dhafer. Laouni3 , Al Akrem. Hayouni4, Moktar. Hamdi2, and Jalloul. Bouajila1
1.Université de Toulouse, Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique UMR CNRS 5623, Université Paul-Sabatier, 118 route de Narbonne, F-31062 Toulouse, France
2.Laboratoire d’Ecologie et de Technologie Microbienne, Institut National des Sciences Appliquées et de la Technologie (INSAT), B.P. 676, 1080 Tunis, Tunisie
3.Laboratoire de transmission, contrôle et immunologie des infections Institut Pasteur Tunis
4.Centre de Biotechnologie à l'Ecopark de Borj-Cédria,Laboratoire des Substances Bioactives, C BP-901 Hammam Lif. Tunisia
Abstract—The Globularia alypum methanolic extract (GAME) was evaluated for the anticholinesterase, anti 5- lipoxygenase, NO production inhibitory activities and the transcriptional regulation pathway. Interestingly, GAME showed an important anti-inflammatory activity in a dose dependant manner, and inhibited nitric oxide (NO) production via transcriptional regulation of iNOS gene by (66%) at 150mg/L in IFN-γ/LPS stimulated RAW 264.7 macrophages. In addition, both Globularia alypum showed a 5-Lipoxygenase inhibitory activity with IC50 value of 79±0.8mg/L. Acetyl-cholinesterase inhibition was assessed by modification of the Ellman’s method. Globularia alypum exhibited a strong activity against cholinesterase with IC50 value 9.33±0.47mg/L. The data suggest that Globularia alypum extract could be used as a natural inhibitor of oxidation and alzheimer disease, and since GAME induced a potent anti-inflammatory suggest its potent use for the treatment of inflammatory diseases.

Index Terms—Globularia alypum, anti-inflammatory activity, anti- cholinesterase.

Cite: Daycem. Khlifi, Rabiaa Manel. Sghaier, Dhafer. Laouni, Al Akrem. Hayouni, Moktar. Hamdi, and Jalloul. Bouajila, "Anti-Inflammatory and Acetylcholinesterase Inhibition Activities of Globularia Alypum", Journal of Medical and Bioengineering, Vol. 2, No. 4, pp. 232-237, December 2013. Doi: 10.12720/jomb.2.4.232-237
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