1. How to submit my research paper? What’s the process for publication of my paper?
The journal receives submitted manuscripts via email only. Please submit your research paper in .doc or .pdf format to the submission email: jomb@ejournal.net.
2.Can I submit an abstract?
The journal publishes full research papers. So only full paper submission... [Read More]

Designing New Vanillin Schiff Bases and their Antibacterial Studies

Sridevi Chigurupati
Faculty of Pharmacy, AIMST University, Semeling, 08100, Bedong, Kedah, Malaysia
Abstract—The antimicrobial drugs occupy a unique niche in the history of medicine. A series of vanillin substituted Schiff bases (SB-1 to SB-6) were synthesized using vanillin and various aromatic amines in presence of a basic catalyst, triethyl amine. The synthesized compounds were authenticated by Thin Layer Chromatography (TLC), Ultraviolet-Visible, Fourier Transformer-Infrared (FT-IR), Nuclear Magnetic Resonance (NMR) and mass spectroscopic techniques. The Antibacterial activity of the synthesized compounds was studied using disc diffusion method and the concentration was fixed using Minimum inhibitory concentration by test tube dilution method using Gentamicin as standard drug. The antibacterial study revealed that compounds SB-5 and SB-6 showed excellent activity against gram positive bacteria: B.subtilis and S.aureus and gram negative bacteria: P.aeruginosa and K. pneumoniae. All the six Schiff bases showed excellent activity against B. subtilis.

Index Terms—vanillin, aromatic amines, schiff bases, antibacterial activity, test tube dilution method, minimum inhibitory concentration, disc diffusion method

Cite: Sridevi Chigurupati, "Designing New Vanillin Schiff Bases and their Antibacterial Studies," Journal of Medical and Bioengineering, Vol. 4, No. 5, pp. 363-366, October 2015. Doi: 10.12720/jomb.4.5.363-366
Copyright © 2013-2016 Journal of Medical and Bioengineering. All Rights Reserved
E-mail: jomb@ejournal.net