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Nanogold Mediated the Neuroprotection in Mutant Huntingtin Expressing Neuronal Cells

Ming-Chang Chiang1,2, Shiang-Jiuun Chen3, Chia-Hui Yen2,4 , Rong-Nan Huang5, and Han-Min Chen6
1.Department of Life Science, Fu Jen Catholic University
2.Terry Whole Brain & Potential Development Center, New Taipei City, Taiwan
3.Department of Life Science, Institute of Ecology and Evolutionary Biology and TechComm-5, College of Life Science, National Taiwan University, Taipei, Taiwan
4.Department of International Business, Ming Chuan University, Taipei, Taiwan
5.Department of Entomology and Research Center for Plant-Medicine, National Taiwan University, Taipei, Taiwan
6.Department of Life Science, and Graduate Institute of Applied Science and Engineering, Fu Jen Catholic University, New Taipei City, Taiwan
Abstract—Huntington disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (Htt) gene. The resultant mutant Htt protein (mHtt) forms aggregates in the brain and causes devastating neuronal degeneration. However, to date, no well describe the effects of nanogold on neurodegenerative disease. The protective effects appeared to be exerted by a direct activation of nanogold protected N2A cells from the mHtt-evoked mHtt aggregates in fluorescence microscope, proteasomes dysfunction by proteasome assay kit and HSP profiles by Q-PCR. Moreover, we report here that nanogold normalized the cell survivability by MTT assay and activity of caspase-3 by caspase fluorometric protease kit in the mHtt expressing N2A cells. These findings and project will extend our understanding of the protection and molecular mechanism of nanogold in mHtt expressing N2A cells. Based on this results provide novel insights into the functions of nanogold in HD, and might facilitate the concept that the nanogold can be a potential therapeutic target in treating HD.
 
Index Terms—nanogold, neuroprotection, neurodegenerative

Cite: Ming-Chang Chiang, Shiang-Jiuun Chen, Chia-Hui Yen, Rong-Nan Huang, and Han-Min Chen, "Nanogold Mediated the Neuroprotection in Mutant Huntingtin Expressing Neuronal Cells," Journal of Medical and Bioengineering, Vol. 4, No. 3, pp. 250-253, June 2015. Doi: 10.12720/jomb.4.3.250-253
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