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Sustainable Formation of Curcumin Nanoparticle: Stirred Tank and Confined Impinging Jet Reactor

Yue Yang and Kunn Hadinoto Ong
Nanyang Technological University, Singapore
Abstract—As natural extract from tumeric, curcumin has driven many people interests. However, the wide application for curcumin is limited by its poorly water solubility. This study explored the possibility to prepare curcumin nanoparticles with a sustainable precipitation by applying pH-shift and avoiding organic solvents. With Pluronic F68 as the surfacatant, this study used two modes of operation, stirred tanks and confined impinging jet reactors, for precipitating curcumin. The effects of energy dissipation, and drug-surfactant mass ratio on particle size discussed. As a result, curcumin nanoparticles with size ranging from 180 to 350 nm and drug loading as high as 87.5% were obtained. We noticed that nanoparticle size decreases with stirring speeds for stirred tanks, but plays a less important role in confined impinging jet reactor. The influence of drug/surfactant mass ratio was more significant in controlling particle size.

Index Terms—pH-shift driven precipitation, curcumin, drug nanoparticles, sustainable, poorly water soluble drug Index

Cite: Yue Yang and Kunn Hadinoto Ong, "Sustainable Formation of Curcumin Nanoparticle: Stirred Tank and Confined Impinging Jet Reactor," Journal of Medical and Bioengineering, Vol. 4, No. 2, pp. 154-158, April 2015. Doi: 10.12720/jomb.4.2.154-158
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