Abstract—Change in gene expression values (due to mutation) is responsible for the evolution of complex organs in different creatures. Here we are carrying out our analysis in between two very closely related primates Human and Chimpanzee. Both Chimpanzee and Human are extant taxa evolution from a common ancestor due to the change in expression levels of genes in different organs. Change in expression levels of genes across various organs happen to be the key driving factor towards evolution of closely related primates. In this analysis we are comparing the extra features/functionalities in Human with respect to Chimpanzee via correlation based linear dependency as well as mutual-information based non-linear dependency between the relevant differential genes. In general it is clear from the analysis that maximum number of genes with changed expression level occurs in the TESTIS than in the BRAIN. This result is very surprising because it is our common assumption that most of the changes should occur in brain due to enhanced cognitive abilities and some recent literatures which focus on Transcription Factor (TF) genes of brain with differential expression between Human and Chimpanzee as a key factor of evolution. So, this turns out to be an important finding.

Index Terms—correlation, mutual information, fuzzy c means clustering, kegg pathways

Cite: Aurpan Majumder and Mrityunjay Sarkar, "Exploring Differential Nature of Human and Chimpanzee Organs through Linear Correlative and MI Measures," Journal of Medical and Bioengineering, Vol. 4, No. 1, pp. 12-18, February 2015. Doi: 10.12720/jomb.4.1.12-18