Abstract—The work presented in this thesis concerns the preparation, characterization and biological evaluation of Schiff bases derived from amoxycillin, cephalexin, sulphamethoxazole and trimethoprim, and 2, 5-hydroxybenzaldehyde. In these complexes an amino group available in the drug substances was allowed to react with 2, 5-hydroxybenzaldehyde, separately, to obtain Schiff bases which were, subsequently,The Schiff bases prepared were: 2, 5-hydroxybensalideneamoxycillin, 2, 5-hydroxybenzalidenecephalexin, 2, 5-hydroxybenzalidenesulphamethoxazole, 2, 5-hydroxybenzalidenetrimetho-prim, The Schiff base ligands were characterized by microanalytical, thermogravimetric, magnetic and spectroscopic data. All the compounds under investigation possess antibacterial activity.The antibacterial activity showed the following trend: Schiff base ligands > parent drugs. The Schiff bases derived from cephalexin showed substantially enhanced activity against P. aeruginosa as compared with the parent drug. All Schiff Base were also found to be active against kaolin paw oedema whereas the parent drugs were inactive.

Index Terms—amoxicillin, cephalexin, ligands,untibacteria, schiff bases

Cite: Abdulbaset A. Elgellal and Ahmed M. Alshadly, "Preparation Characterization and Biological Evaluation of Schiff-Base of Some Drug Substances," Journal of Medical and Bioengineering, Vol. 3, No. 3, pp. 187-189, September 2014. Doi: 10.12720/jomb.3.3.187-189