1. How to submit my research paper? What’s the process for publication of my paper?
The journal receives submitted manuscripts via email only. Please submit your research paper in .doc or .pdf format to the submission email: jomb@ejournal.net.
2.Can I submit an abstract?
The journal publishes full research papers. So only full paper submission... [Read More]

Docking Study of β-glucosidase B (BglB) from P. Polymyxca with Cellobiose and Cellotetrose

Nur Shima Fadhilah Mazlan1 and Nurul Bahiyah Ahmad Khairudin2
1.Malaysia-Japan International Institute of Technology
2.Universiti Teknologi Malaysia Kuala Lumpur, Malaysia
Abstract—Beta-glucosidase (3.2.1.21) plays an essential role in the removal of non-reducing terminal glucosyl residues from sacharides and glycosides. Recently, beta-glucosidase has been of interest for biomass conversion that acts in synergy with two other enzymes, endo-glucanase and exo-glucanase. However, there is not much information regarding the molecular interactions of beta-glucosidase with cellobiose. Thus, this study reports on the binding modes between beta-glucosidase from glycoside hydrolase family 1 namely BglB with cellobiose and cellotetrose via molecular docking method. Further analysis on the hydrophobic interactions revealed the key residues involved in forming hydrogen bonds (h-bond) with the substrates. The active residue were identified to be Gln22, Glu167, Glu356, Glu402 and Trp402 .These findings may provide valuable insigths in designing beta-glucosidase with higher cellulose-hydrolyzing efficiency.

Index Terms—beta-glucosidase, binding site, molecular docking, cellobiose, protein ligand interaction

Cite: Nur Shima Fadhilah Mazlan and Nurul Bahiyah Ahmad Khairudin, "Docking Study of β-glucosidase B (BglB) from P. Polymyxca with Cellobiose and Cellotetrose," Journal of Medical and Bioengineering, Vol. 3, No. 2, pp. 78-83, June 2014. Doi: 10.12720/jomb.3.2.78-83
Array
Copyright © 2013-2016 Journal of Medical and Bioengineering. All Rights Reserved
E-mail: jomb@ejournal.net